期刊
STEM CELLS TRANSLATIONAL MEDICINE
卷 3, 期 3, 页码 290-298出版社
WILEY
DOI: 10.5966/sctm.2013-0127
关键词
Pluripotent stem cells; Parthenogenesis; Histocompatibility; Imprinting
资金
- Leducq Foundation
- National Institutes of Health [T32HD007133, R01HD063276, R01HD057121, R01HD059946, R01EY021214, P51OD011092]
Embryonic stem cells (ESCs) have the potential to provide unlimited cells and tissues for regenerative medicine. ESCs derived from fertilized embryos, however, will most likely be rejected by a patient's immune system unless appropriately immunomatched. Pluripotent stem cells (PSCs) genetically identical to a patient can now be established by reprogramming of somatic cells. However, practical applications of PSCs for personalized therapies are projected to be unfeasible because of the enormous cost and time required to produce clinical-grade cells for each patient. ESCs derived from parthenogenetic embryos (pESCs) that are homozygous for human leukocyte antigens may serve as an attractive alternative for immunomatched therapies for a large population of patients. In this study, we describe the biology and genetic nature of mammalian parthenogenesis and review potential advantages and limitations of pESCs for cell-based therapies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据