期刊
STEM CELLS TRANSLATIONAL MEDICINE
卷 3, 期 5, 页码 632-635出版社
WILEY
DOI: 10.5966/sctm.2013-0203
关键词
Heterogeneity; Plasticity; Criteria
资金
- NIH HHS [P40 OD011050] Funding Source: Medline
There has been great interest in research and clinical trials with the adult stem/progenitor cells referred to as mesenchymal stem/stromal cells (MSCs). However, there are no definitive markers for the cells and no assays that would reflect the therapeutic efficacy of the cells in vivo. There are in effect no adequate release criteria that define the quality or efficacy of the cells. The problems are compounded by the fact that a variety of different protocols has been used to isolate the cells and expand them in culture. The result is that many publications have used MSCs with different properties, frequently without the investigators being aware of the differences. As a partial solution to these problems, we have devised a simple table to record in-process data on the preparation of MSCs. We suggest that comparisons of data generated by different laboratories would be facilitated if similar in-process data, probably as supplemental materials, were included in publications using MSCs.
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