期刊
STEM CELLS TRANSLATIONAL MEDICINE
卷 2, 期 4, 页码 316-324出版社
ALPHAMED PRESS
DOI: 10.5966/sctm.2012-0136
关键词
Clinical trials; Differentiation; Stem cell transplantation; Tissue regeneration; Bone
资金
- Second University of Naples [2009-10]
- European Union [01_02834 2011/14]
Mesenchymal stem cells deriving from dental pulp differentiate into osteoblasts capable of producing bone. In previous studies, we extensively demonstrated that, when seeded on collagen I scaffolds, these cells can be conveniently used for the repair of human mandible defects. Here, we assess the stability and quality of the regenerated bone and vessel network 3 years after the grafting intervention, with conventional procedures and in-line holotomography, an advanced phase-imaging method using synchrotron radiation that offers improved sensitivity toward low-absorbing structures. We found that the regenerated tissue from the graft sites was composed of a fully compact bone with a higher matrix density than control human alveolar spongy bone from the same patient. Thus, the regenerated bone, being entirely compact, is completely different from normal alveolar bone. Although the bone regenerated at the graft sites is not of the proper type found in the mandible, it does seem to have a positive clinical impact. In fact, it creates steadier mandibles, may well increase implant stability, and, additionally, may improve resistance to mechanical, physical, chemical, and pharmacological agents. STEM CELLS TRANSLATIONAL MEDICINE 2013;2:316-324
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