期刊
STEM CELL REPORTS
卷 5, 期 5, 页码 843-855出版社
CELL PRESS
DOI: 10.1016/j.stemcr.2015.09.013
关键词
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资金
- Swedish Cancer Society
- Swedish Research Council
- H&G Jeanssons Foundation
- Swedish Foundation for Strategic Research
- Ragnar Soderberg Foundation
- European Molecular Biology Organization
- Wellcome Trust [098357/Z/12/Z]
- EU FP7 ITN Healing Network
- Knut and Alice Wallenberg Foundation
- Center for Innovative Medicine
- Royal Institute of Technology, Sweden
- Knut and Alice Wallenberg Foundation, Karolinska Institutet, Huddinge, Sweden
- Wellcome Trust [098357/Z/12/Z] Funding Source: Wellcome Trust
The dynamics and interactions between stem cell pools in the hair follicle (HF), sebaceous gland (SG), and interfollicular epidermis (IFE) of murine skin are still poorly understood. In this study, we used multicolor lineage tracing to mark Lgr6-expressing basal cells in the HF isthmus, SG, and IFE. We show that these Lgr6(+) cells constitute long-term self-renewing populations within each compartment in adult skin. Quantitative analysis of clonal dynamics revealed that the Lgr6(+) progenitor cells compete neutrally in the IFE, isthmus, and SG, indicating population asymmetry as the underlying mode of tissue renewal. Transcriptional profiling of Lgr6(+) and Lgr6(-) cells did not reveal a distinct Lgr6(-) associated gene expression signature, raising the question of whether Lgr6 expression requires extrinsic niche signals. Our results elucidate the interrelation and behavior of Lgr6(+) populations in the IFE, HF, and SG and suggest population asymmetry as a common mechanism for homeostasis in several epithelial skin compartments.
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