期刊
PROTEIN & CELL
卷 4, 期 12, 页码 904-910出版社
HIGHER EDUCATION PRESS
DOI: 10.1007/s13238-013-3084-z
关键词
Hippo signaling; actin cytoskeleton; negative feedback; growth control; development
类别
资金
- National Science Foundation
Hippo signaling plays a crucial role in growth control and tumor suppression by regulating cell proliferation, apoptosis, and differentiation. How Hippo signaling is regulated has been under extensive investigation. Over the past three years, an increasing amount of data have supported a model of actin cytoskeleton blocking Hippo signaling activity to allow nuclear accumulation of a downstream effector, Yki/Yap/Taz. On the other hand, Hippo signaling negatively regulates actin cytoskeleton organization. This review provides insight on the mutual regulatory mechanisms between Hippo signaling and actin cytoskeleton for a tight control of cell behaviors during animal development, and points out outstanding questions for further investigations.
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