期刊
PROTEIN & CELL
卷 1, 期 4, 页码 342-354出版社
SPRINGEROPEN
DOI: 10.1007/s13238-010-0054-6
关键词
influenza A virus; hemagglutinin; viral entry; antiviral drugs; vaccines
类别
资金
- US NIH [AI68002, AI46221]
- Natural Science Foundation of China [30772602]
- Ministry of Education's New Century Talent Program [NCET-06-0753]
Seasonal influenza epidemics and influenza pandemics caused by influenza A virus (IAV) has resulted in millions of deaths in the world. The development of anti-IAV vaccines and therapeutics is urgently needed for prevention and treatment of IAV infection and for controlling future influenza pandemics. Hemagglutinin (HA) of IAV plays a critical role in viral binding, fusion and entry, and contains the major neutralizing epitopes. Therefore, HA is an attractive target for developing anti-IAV drugs and vaccines. Here we have reviewed the recent progress in study of conformational changes of HA during viral fusion process and development of HA-based antiviral therapeutics and vaccines.
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