期刊
PROTEIN & CELL
卷 1, 期 3, 页码 227-236出版社
HIGHER EDUCATION PRESS
DOI: 10.1007/s13238-010-0032-z
关键词
DNA replication licensing; rereplication; protein modification
类别
资金
- Welch Foundation
Eukaryotic DNA replication is tightly restricted to only once per cell cycle in order to maintain genome stability. Cells use multiple mechanisms to control the assembly of the prereplication complex (pre-RC), a process known as replication licensing. This review focuses on the regulation of replication licensing by posttranslational modifications of the licensing factors, including phosphorylation, ubiquitylation and acetylation. These modifications are critical in establishing the pre-RC complexes as well as preventing rereplication in each cell cycle. The relationship between rereplication and diseases, including cancer and virus infection, is discussed as well.
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