期刊
PROTEIN & CELL
卷 1, 期 11, 页码 999-1010出版社
HIGHER EDUCATION PRESS
DOI: 10.1007/s13238-010-0131-x
关键词
Polo-like kinase 1; phosphorylation; substrates
类别
Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. In this short review, we briefly summarized the well-established functions modulated by Plk1 during mitosis. Beyond mitosis, we focused mainly on the unexpected processes in which Plk1 emerges as a critical player, including microtubule dynamics, DNA replication, chromosome dynamics, p53 regulation, and recovery from the G2 DNA-damage checkpoint. Our discussion is mainly based on the critical substrates targeted by Plk1 during these cellular events and the functional significance associated with each phosphorylation event.
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