期刊
POLYMERS
卷 6, 期 2, 页码 264-279出版社
MDPI AG
DOI: 10.3390/polym6020264
关键词
RGD interaction with integrins; crosslinked polymer networks; poly(2-oxazoline)s; cancer cell recognition
资金
- Austrian Government
- State Government of Styria
- State Government of Upper Austria
- Schuchtermann-Stiftung, Germany
Poly(2-oxazoline) networks with varying swelling degrees and varying hydrophilicity can be synthesized from 2-ethyl-2-oxazoline, 2-nonyl-2-oxazoline, 2-9'-decenyl-2-oxazoline and 2,2'-tetramethylene-bis-2-oxazoline in one-pot/one-step strategies. These gels can be loaded with organic molecules, such as fluorescein isothiocyanate, either during the polymerization (covalent attachment of the dye) or according to post-synthetic swelling/deswelling strategies (physical inclusion of the dye). Surface functionalization of ground gels by thiol-ene reactions with cysteine-bearing peptides exhibiting the arginine-glycine-aspartic acid (RGD) motif yields microparticles with enhanced recognition of human cancer cells compared to healthy endothelial cells.
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