期刊
POLYMERS
卷 2, 期 4, 页码 418-439出版社
MDPI AG
DOI: 10.3390/polym2040418
关键词
alpha-hydroxy acids; polyesters; toxicity; degradation; drug delivery
资金
- Israel Science Foundation [591/08]
- Alex Grass Center for Drug Design and synthesis of Novel Therapeutics
New polymers were synthesized from alpha-hydroxy acids derived from the natural amino acids Ile, Leu, Phe, and Val, combined with lactic acid, glycolic acid and 6-hydroxyhexanoic acid by direct condensation. The toxicity was determined and the degradation process of these polyesters was investigated under physiological conditions by analyzing the composition of the degraded polymers and the oligomers cleaved in the buffer medium. The polymers were found to be non toxic to two cell lines. Polymers displayed a biphasic degradation behavior. In most cases, a linear relationship was found between the weight loss constant and the hydrophobicity of the polymers, Log P. Regarding the second stage of weight loss, it is apparent that polymers derived from alpha-hydroxy(L)isoleucine ((L)HOIle) and alpha-hydroxy(L)Valine ((L)HOVal) degraded much faster than those derived from alpha-hydroxy(L)leucine ((L)HOLeu) and alpha-hydroxy(L)phenylalanine ((L)HOPhe), probably due to different spatial orientation of the side chains. Copolymers of 6-hydroxyhexanoic acid displayed slow degradation rates as expected, whereas the degradation profile of copolymers of lactic acid was similar to the other homopolymers. These new polyesters may serve as potential biocompatible materials for medical applications.
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