期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 11, 期 -, 页码 1509-1513出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.11.164
关键词
chiral diamines; enantioselective reduction; epinastine; mianserin; ruthenium complexes
A simple enantioselective synthetic procedure for the preparation of mianserin and epinastine in optically pure form is described. The key step in the synthetic pathway is the asymmetric reduction of the cyclic imine using asymmetric transfer hydrogenation conditions.
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