期刊
PLOS PATHOGENS
卷 9, 期 10, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.ppat.1003657
关键词
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资金
- NIH [AI058113, GM062116, GM098791, GM080533-06]
- CDC
- Skaggs Institute for Chemical Biology
- DOE Office of Biological and Environmental Research
- NIH, National Center for Research Resources, Biomedical Technology Program [P41RR001209]
- National Institute of General Medical Sciences
- National Cancer Institute [Y1-CO-1020]
- NIGMS [Y1-GM-1104]
- U.S. Department of Energy, Basic Energy Sciences, Office of Science [DE-AC02-06CH11357, W-31-109-Eng-38]
- Global Disease Detection program TSC funds in the Centers for Disease Control and Prevention, Atlanta, Georgia
- collaborative Centers for Disease Control and Prevention-University of Georgia Seed Award
Aquatic birds harbor diverse influenza A viruses and are a major viral reservoir in nature. The recent discovery of influenza viruses of a new H17N10 subtype in Central American fruit bats suggests that other New World species may similarly carry divergent influenza viruses. Using consensus degenerate RT-PCR, we identified a novel influenza A virus, designated as H18N11, in a flat-faced fruit bat (Artibeus planirostris) from Peru. Serologic studies with the recombinant H18 protein indicated that several Peruvian bat species were infected by this virus. Phylogenetic analyses demonstrate that, in some gene segments, New World bats harbor more influenza virus genetic diversity than all other mammalian and avian species combined, indicative of a long-standing host-virus association. Structural and functional analyses of the hemagglutinin and neuraminidase indicate that sialic acid is not a ligand for virus attachment nor a substrate for release, suggesting a unique mode of influenza A virus attachment and activation of membrane fusion for entry into host cells. Taken together, these findings indicate that bats constitute a potentially important and likely ancient reservoir for a diverse pool of influenza viruses.
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