期刊
PLOS PATHOGENS
卷 8, 期 5, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.ppat.1002607
关键词
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资金
- Netherlands Organization of Scientific Research (NWO)
- Royal Netherlands Academy of Arts and Sciences (KNAW)
- WOTRO/NACCAP
- European Commission
- Bill & Melinda Gates Foundation Grand Challenges in Global Health [GC6#74, GC12#82]
- Top Institute Pharma
- German Ministry for Science and Education (BMBF)
- Max Planck Society
In this review we discuss recent progress in the development, testing, and clinical evaluation of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has been made in TB vaccine research and development: from a pipeline virtually empty of new TB candidate vaccines in the early 1990s, to an era in which a dozen novel TB vaccine candidates have been and are being evaluated in human clinical trials. In addition, innovative approaches are being pursued to further improve existing vaccines, as well as discover new ones. Thus, there is good reason for optimism in the field of TB vaccines that it will be possible to develop better vaccines than BCG, which is still the only vaccine available against TB.
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