期刊
PLOS PATHOGENS
卷 7, 期 12, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.ppat.1002421
关键词
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资金
- Fundacao para a Ciencia e Tecnologia [PTDC/SAU-MII/75696/2006, PTDC/BIA-MIC/100747/2008, SFRH/BD/28440/2006, SFRH/BPD/23838/2005]
- EMBO [ALTF 1042 2007]
- Medical Research Council UK [G0300170]
- Wellcome Trust [WT087680]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/28440/2006, SFRH/BPD/23838/2005, PTDC/BIA-MIC/100747/2008, PTDC/SAU-MII/75696/2006] Funding Source: FCT
- Medical Research Council [G0300170] Funding Source: researchfish
- MRC [G0300170] Funding Source: UKRI
The cell wall of Gram-positive bacteria is a complex network of surface proteins, capsular polysaccharides and wall teichoic acids (WTA) covalently linked to Peptidoglycan (PG). The absence of WTA has been associated with a reduced pathogenicity of Staphylococcus aureus (S. aureus). Here, we assessed whether this was due to increased detection of PG, an important target of innate immune receptors. Antibiotic-mediated or genetic inhibition of WTA production in S. aureus led to increased binding of the non-lytic PG Recognition Protein-SA (PGRP-SA), and this was associated with a reduction in host susceptibility to infection. Moreover, PGRP-SD, another innate sensor required to control wild type S. aureus infection, became redundant. Our data imply that by using WTA to limit access of innate immune receptors to PG, under-detected bacteria are able to establish an infection and ultimately overwhelm the host. We propose that different PGRPs work in concert to counter this strategy.
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