期刊
PEERJ
卷 3, 期 -, 页码 -出版社
PEERJ INC
DOI: 10.7717/peerj.934
关键词
High pathogenicity avian influenza; HPAI; H5N8; Migratory birds; Siberia; Korea; Bayesian; Coalescence
资金
- Biotechnology and Biological Sciences Research Council [BBS/E/I/00001025, BBS/E/I/00001708, BB/L004240/1, BBS/E/I/00001422, BBS/E/I/00001759, BB/L026341/1] Funding Source: researchfish
- BBSRC [BBS/E/I/00001759, BBS/E/I/00001708, BB/L026341/1, BB/L004240/1, BBS/E/I/00001422] Funding Source: UKRI
The origin of recent parallel outbreaks of the high pathogenicity H5N8 avian flu virus in Europe and in Japan can be traced to a single source population, which has most likely been spread by migratory birds. By using Bayesian coalescent methods to analyze the DNA sequences of the virus to find the times for divergence and combining this sequence data with bird migration data we can show the most likely locations and migratory pathways involved in the origin of the current outbreak. This population was most likely located in the Siberian summer breeding grounds of long-range migratory birds. These breeding grounds provide a connection between different migratory flyways and explain the current outbreaks in remote locations. By combining genetic methods and epidemiological data we can rapidly identify the sources and the dispersion pathways for novel avian influenza outbreaks.
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