期刊
PLOS PATHOGENS
卷 7, 期 10, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.ppat.1002270
关键词
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资金
- Wellcome Trust
- Medical Research Council
- National Institutes of Health
- National Cancer Institute, National Institutes of Health [HHSN261200800001E]
- NIH, National Cancer Institute, Center for Cancer Research
- National Institutes of Health, National Institute of Child Health and Human Development [1 R01 HD41224]
- National Institute on Drug Abuse [R01-DA-04334, R01-DA-12568, R01-DA-16078]
- Medical Research Council [G0601072] Funding Source: researchfish
- MRC [G0601072] Funding Source: UKRI
Killer cell immunoglobulin-like receptors (KIRs) influence both innate and adaptive immunity. But while the role of KIRs in NK-mediated innate immunity is well-documented, the impact of KIRs on the T cell response in human disease is not known. Here we test the hypothesis that an individual's KIR genotype affects the efficiency of their HLA class I-mediated antiviral immune response and the outcome of viral infection. We show that, in two unrelated viral infections, hepatitis C virus and human T lymphotropic virus type 1, possession of the KIR2DL2 gene enhanced both protective and detrimental HLA class I-restricted anti-viral immunity. These results reveal a novel role for inhibitory KIRs. We conclude that inhibitory KIRs, in synergy with T cells, are a major determinant of the outcome of persistent viral infection.
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