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注意:仅列出部分参考文献,下载原文获取全部文献信息。Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor
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Heather M. Marshall et al.
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LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration
Ming-Chieh Shun et al.
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Nidhanapati K. Raghavendra et al.
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M Li et al.
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Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75
P Cherepanov et al.
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Processing of viral DNA ends channels the HIV-1 integration reaction to concerted integration
M Li et al.
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Genetic analyses of conserved residues in the carboxyl-terminal domain of human immunodeficiency virus type 1 integrase
R Lu et al.
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Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75
P Cherepanov et al.
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Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering
M Vanegas et al.
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Correction of X-ray intensities from single crystals containing lattice-translocation defects
JM Wang et al.
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HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases
E Devroe et al.
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HIV-1 integrase crosslinked oligomers are active in vitro
A Faure et al.
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LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes
M Llano et al.
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Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication
R Lu et al.
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Coot:: model-building tools for molecular graphics
P Emsley et al.
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Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase
P Cherepanov et al.
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Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase
K Zhu et al.
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LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells
G Maertens et al.
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An amino acid in the central catalytic domain of three retroviral integrases that affects target site selection in nonviral DNA
AL Harper et al.
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Functional oligomeric state of avian sarcoma virus integrase
KK Bao et al.
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PHENIX:: building new software for automated crystallographic structure determination
PD Adams et al.
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Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders
X Wu et al.
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Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein
JY Wang et al.
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Use of patient-derived human immunodeficiency virus type 1 integrases to identify a protein residue that affects target site selection
AL Harper et al.
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Use of TLS parameters to model anisotropic displacements in macromolecular refinement
MD Winn et al.
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Determinants of Mg2+-dependent activities of recombinant human immunodeficiency virus type 1 integrase
H Leh et al.
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JCH Chen et al.
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Three-dimensional structure of the Tn5 synaptic complex transposition intermediate
DR Davies et al.
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Werner G. Krebs et al.
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Identification of critical amino acid residues in human immunodeficiency virus type 1 IN required for efficient proviral DNA formation at steps prior to integration in dividing and nondividing cells
N Tsurutani et al.
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E Mossessova et al.
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X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293) - An initial glance of the viral DNA binding platform
ZG Chen et al.
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Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase
ZN Yang et al.
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