期刊
PLOS NEGLECTED TROPICAL DISEASES
卷 8, 期 8, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pntd.0003088
关键词
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资金
- National Mega Project on Major Infectious Disease Prevention [2012ZX10004-213]
- Chinese Ministry of Education [311030]
- Natural Science Foundation of China [81330058, 81272417, 81102370]
- Guangdong Recruitment Program of Creative Research Groups [2009010058]
- National Science and Technique Major Project [201305017, 2012ZX09102101-017]
- Key Science and Technique Research Project of Guangzhou City [12B292060029]
MicroRNAs have been shown to contribute to a repertoire of host-pathogen interactions during viral infection. Our previous study demonstrated that microRNA-30e* (miR-30e*) directly targeted the I kappa B alpha 3'-UTR and disrupted the NF-kappa B/I kappa B alpha negative feedback loop, leading to hyperactivation of NF-kappa B. This current study investigated the possible role of miR-30e* in the regulation of innate immunity associated with dengue virus (DENV) infection. We found that DENV infection could induce miR-30e* expression in DENV-permissive cells, and such an overexpression of miR-30e* upregulated IFN-beta and the downstream IFN-stimulated genes (ISGs) such as OAS1, MxA and IFITM1, and suppressed DENV replication. Furthermore, suppression of I kappa B alpha mediates the enhancing effect of miR-30e* on IFN-beta-induced antiviral response. Collectively, our findings suggest a modulatory role of miR-30e* in DENV induced IFN-beta signaling via the NF-kappa B-dependent pathway. Further investigation is needed to evaluate whether miR-30e* has an anti-DENV effect in vivo.
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