期刊
PLOS MEDICINE
卷 5, 期 7, 页码 1091-1101出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pmed.0050152
关键词
-
Background Several studies have suggested that diabetes mellitus ( DM) increases the risk of active tuberculosis (TB). The rising prevalence of DM in TB- endemic areas may adversely affect TB control. We conducted a systematic review and a meta- analysis of observational studies assessing the association of DM and TB in order to summarize the existing evidence and to assess methodological quality of the studies. Methods and Findings We searched the PubMed and EMBASE databases to identify observational studies that had reported an age-adjusted quantitative estimate of the association between DM and active TB disease. The search yielded 13 observational studies (n = 1,786,212 participants) with 17,698 TB cases. Random effects meta-analysis of cohort studies showed that DM was associated with an increased risk of TB (relative risk 3.11, 95% CI 2.27 - 4.26). Case-control studies were heterogeneous and odds ratios ranged from 1.16 to 7.83. Subgroup analyses showed that effect estimates were higher in non- North American studies. Conclusion DM was associated with an increased risk of TB regardless of study design and population. People with DM may be important targets for interventions such as active case finding and treatment of latent TB and efforts to diagnose, detect, and treat DM may have a beneficial impact on TB control.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据