期刊
NUCLEUS
卷 6, 期 4, 页码 279-288出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19491034.2015.1062194
关键词
SRPK1; PRP4K; CLK1; cancer; alternative mRNA splicing
类别
资金
- Canadian Breast Cancer Foundation (CBCF)-Atlantic operating grant
- CBCF-Atlantic
- CIBC Graduate Scholarship in Medical Research trainee award from the BHCRI
- CBCF - Atlantic
- Canadian Cancer Society, Nova Scotia Division as part of The Terry Fox Foundation Strategic Health Research Training (STIHR) Program in Cancer Research at the Canadian Institutes of Health Research (CIHR)
Alternative pre-mRNA splicing in higher eukaryotes enhances transcriptome complexity and proteome diversity. Its regulation is mediated by a complex RNA-protein network that is essential for the maintenance of cellular and tissue homeostasis. Disruptions to this regulatory network underlie a host of human diseases and contribute to cancer development and progression. The splicing kinases are an important family of pre-mRNA splicing regulators, , which includes the CDC-like kinases (CLKs), the SRSF protein kinases (SRPKs) and pre-mRNA splicing 4 kinase (PRP4K/PRPF4B). These splicing kinases regulate pre-mRNA splicing via phosphorylation of spliceosomal components and serine-arginine (SR) proteins, affecting both their nuclear localization within nuclear speckle domains as well as their nucleo-cytoplasmic shuttling. Here we summarize the emerging evidence that splicing kinases are dysregulated in cancer and play important roles in both tumorigenesis as well as therapeutic response to radiation and chemotherapy.
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