期刊
PLOS GENETICS
卷 8, 期 7, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1002854
关键词
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资金
- Fonds National de la Recherche Scientifique (FNRS
- FRIA fellowship), of the Communaute Francaise de Belgique (BIOMOD Action de Recherche Concertee)
- Marie Curie Fellowship (IOF program) from the European Union
- Belgian Science Policy Organisation (SSTC Genefunc PAI)
- Walloon Ministry of Agriculture
We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.
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