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Martin C. Herzig et al.
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Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities
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A QUICK Screen for Lrrk2 Interaction Partners - Leucine-rich Repeat Kinase 2 is Involved in Actin Cytoskeleton Dynamics
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Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2
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LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
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PLOS ONE (2011)
Membrane Localization of LRRK2 Is Associated with Increased Formation of the Highly Active LRRK2 Dimer and Changes in Its Phosphorylation
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Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila
Tomoko Kanao et al.
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Reevaluation of Phosphorylation Sites in the Parkinson Disease-associated Leucine-rich Repeat Kinase 2
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Phosphopeptide Analysis Reveals Two Discrete Clusters of Phosphorylation in the N-Terminus and the Roc Domain of the Parkinson-Disease Associated Protein Kinase LRRK2
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Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
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The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation
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ARHGEF7 (BETA-PIX) Acts as Guanine Nucleotide Exchange Factor for Leucine-Rich Repeat Kinase 2
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SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
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GTPase Activity Plays a Key Role in the Pathobiology of LRRK2
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PLOS GENETICS (2010)
The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Identification of the Autophosphorylation Sites of LRRK2
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LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
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Dependence of Leucine-rich Repeat Kinase 2 (LRRK2) Kinase Activity on Dimerization
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Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability - a point of convergence in Parkinsonian neurodegeneration?
Frank Gillardon
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Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis
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The Parkinson Disease Protein Leucine-Rich Repeat Kinase 2 Transduces Death Signals via Fas-Associated Protein with Death Domain and Caspase-8 in a Cellular Model of Neurodegeneration
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Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
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Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein
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Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
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Parkin mediates the degradation-independent ubiquitination of Hsp70
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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
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The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2
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Dynamic and redundant regulation of LRRK2 and LRRK1 expression
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Leucine-rich repeat kinase 2 associates with lipid rafts
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GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease
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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
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Kinase activity of mutant LRRK2 mediates neuronal toxicity
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Golgi localization determinants in ArfGAP1 and in new tissue-specific ArfGAP1 Isoforms
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LRRK2 G2019S as a cause of Parkinson's disease in North African Arabs
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LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews
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The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
CJ Gloeckner et al.
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Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
WW Smith et al.
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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
AB West et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
ArfGAP1 dynamics and its role in COPI coat assembly on Golgi membranes of living cells
W Liu et al.
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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
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SCIENCE (2005)
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SY Lee et al.
JOURNAL OF CELL BIOLOGY (2005)
COP and clathrin-coated vesicle budding: different pathways, common approaches
HT McMahon et al.
CURRENT OPINION IN CELL BIOLOGY (2004)
ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat
JS Yang et al.
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