相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
Ivana Bjedov et al.
CELL METABOLISM (2010)
mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice
David A. Guertin et al.
CANCER CELL (2009)
Tumours with PI3K activation are resistant to dietary restriction
Nada Y. Kalaany et al.
NATURE (2009)
Biochemical characterisation of TCTP questions its function as a guanine nucleotide exchange factor for Rheb
H. Rehmann et al.
FEBS LETTERS (2008)
Re-evaluating the Roles of Proposed Modulators of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling
Xuemin Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
Jingxiang Huang et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
DICKKOPF-4 is induced by TCF/β-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1α, 25-dihydroxyvitamin D3
N. Pendas-Franco et al.
ONCOGENE (2008)
FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatasesy
Yan G. Ni et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling
Kathleen A. Martin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
PRAS40 and PRR5-Like Protein Are New mTOR Interactors that Regulate Apoptosis
Kathrin Thedieck et al.
PLOS ONE (2007)
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
Bruno D. Fonseca et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Identification of Protor as a novel Rictor-binding component of mTOR complex-2
Laura R. Pearce et al.
BIOCHEMICAL JOURNAL (2007)
Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition
E. K-H Han et al.
ONCOGENE (2007)
AKT/PKB signaling: Navigating downstream
Brendan D. Manning et al.
CELL (2007)
Discrete functions of rictor and raptor in cell growth regulation in Drosophila
Gina Lee et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer
Stephen G. Dann et al.
TRENDS IN MOLECULAR MEDICINE (2007)
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
Yasemin Sancak et al.
MOLECULAR CELL (2007)
Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth
Ville Hietakangas et al.
GENES & DEVELOPMENT (2007)
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
Emilie Vander Haar et al.
NATURE CELL BIOLOGY (2007)
Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase
Ya-Chieh Hsu et al.
NATURE (2007)
IRES-mediated functional coupling of transcription and translation amplifies insulin receptor feedback
Michael T. Marr et al.
GENES & DEVELOPMENT (2007)
Phosphatase and feedback regulation of Raf-1 signaling
Amardeep S. Dhillon et al.
CELL CYCLE (2007)
Role of dietary proteins and amino acids in the pathogenesis of insulin resistance
Frederic Tremblay et al.
ANNUAL REVIEW OF NUTRITION (2007)
Patching the gaps in Hedgehog signalling
Rajat Rohatgi et al.
NATURE CELL BIOLOGY (2007)
Function and biological roles of the Dickkopf family of Wnt modulators
C. Niehrs
ONCOGENE (2006)
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα but not S6K1
David A. Guertin et al.
DEVELOPMENTAL CELL (2006)
How flies get their size: genetics meets physiology
Bruce A. Edgar
NATURE REVIEWS GENETICS (2006)
Mutations in the NF-κB signaling pathway:: implications for human disease
G. Courtois et al.
ONCOGENE (2006)
Sprouty and cancer: The first terms report
Ting Ling Lo et al.
CANCER LETTERS (2006)
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
Estela Jacinto et al.
CELL (2006)
Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner
Jennifer E. Skeen et al.
CANCER CELL (2006)
Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability
Chiyo Shiota et al.
DEVELOPMENTAL CELL (2006)
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
Maria A. Frias et al.
CURRENT BIOLOGY (2006)
Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling
Yan G. Ni et al.
CIRCULATION (2006)
Turnover of the active fraction of IRS1 involves Raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis
O. Jameel Shah et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Ras, PI(3)K and mTOR signalling controls tumour cell growth
Reuben J. Shaw et al.
NATURE (2006)
The amino acid sensitive TOR pathway from yeast to mammals
Stephen G. Dann et al.
FEBS LETTERS (2006)
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity
Q Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
JAW/STAT signal transduction: Regulators and implication in hematological malignancies
L Valentino et al.
BIOCHEMICAL PHARMACOLOGY (2006)
TOR signaling in growth and metabolism
S Wullschleger et al.
CELL (2006)
TOR signaling in growth and metabolism
Stephan Wullschleger et al.
CELL (2006)
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
A Tzatsos et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Sprouty proteins: multifaceted negative-feed back regulators of receptor tyrosine kinase signaling
JM Mason et al.
TRENDS IN CELL BIOLOGY (2006)
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
Sung Hee Um et al.
CELL METABOLISM (2006)
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
SF Tavazoie et al.
NATURE NEUROSCIENCE (2005)
Transcriptional feedback control of insulin receptor by dFOXO/FOXO1
O Puig et al.
GENES & DEVELOPMENT (2005)
TGF-β signaling in T cells:: roles in lymphoid and epithelial neoplasia
JJ Letterio
ONCOGENE (2005)
4E-BP functions as a metabolic brake used under stress conditions but not during normal growth
AA Teleman et al.
GENES & DEVELOPMENT (2005)
Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2
BD Manning et al.
GENES & DEVELOPMENT (2005)
Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression
L Ma et al.
GENES & DEVELOPMENT (2005)
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
MK Holz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Rheb binds and regulates the mTOR kinase
X Long et al.
CURRENT BIOLOGY (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Tuberous sclerosis and insulin resistance - Unlikely bedfellows reveal a TORrid affair
OJ Shah et al.
CELL CYCLE (2005)
Dysregulation of the TSC-mTOR pathway in human disease
K Inoki et al.
NATURE GENETICS (2005)
Inparanoid: a comprehensive database of eukaryotic orthologs
KP O'Brien et al.
NUCLEIC ACIDS RESEARCH (2005)
PI3-kinase and TOR: PIKTORing cell growth
CJ Richardson et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2004)
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
RJ Shaw et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Genome-wide RNAi analysis of growth and viability in Drosophila cells
M Boutros et al.
SCIENCE (2004)
Tuberous sclerosis complex:: from Drosophila to human disease
DJ Pan et al.
TRENDS IN CELL BIOLOGY (2004)
Crosstalk between the EGFR and LIN-12/Notch pathways in C-elegans vulval development
AS Yoo et al.
SCIENCE (2004)
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
OJ Shah et al.
CURRENT BIOLOGY (2004)
Argos inhibits epidermal growth factor receptor signalling by ligand sequestration
DE Klein et al.
NATURE (2004)
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
LS Harrington et al.
JOURNAL OF CELL BIOLOGY (2004)
The LKB1 tumor suppressor negatively regulates mTOR signaling
RJ Shaw et al.
CANCER CELL (2004)
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
DS Hwangbo et al.
NATURE (2004)
Tsc2 is not a critical target of Akt during normal Drosophila development
JX Dong et al.
GENES & DEVELOPMENT (2004)
TSC2 mediates cellular energy response to control cell growth and survival
K Inoki et al.
CELL (2003)
Genetic mosaic techniques for studying Drosophila development
SS Blair
DEVELOPMENT (2003)
Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
J Luo et al.
CANCER CELL (2003)
Rhebbing up mTOR - New insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis
DJ Kwiatkowski
CANCER BIOLOGY & THERAPY (2003)
Control of cell number by Drosophila FOXO:: downstream and feedback regulation of the insulin receptor pathway
O Puig et al.
GENES & DEVELOPMENT (2003)
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
H Stocker et al.
NATURE CELL BIOLOGY (2003)
Rheb promotes cell growth as a component of the insulin/TOR signalling network
LJ Saucedo et al.
NATURE CELL BIOLOGY (2003)
GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
DH Kim et al.
MOLECULAR CELL (2003)
Rheb fills a GAP between TSC and TOR
BD Manning et al.
TRENDS IN BIOCHEMICAL SCIENCES (2003)
Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling
T Radimerski et al.
GENES & DEVELOPMENT (2002)
Akt regulates growth by directly phosphorylating Tsc2
CJ Potter et al.
NATURE CELL BIOLOGY (2002)
Altering Drosophila S6 kinase activity is consistent with a role for S6 kinase in growth
H Barcelo et al.
GENESIS (2002)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
XS Gao et al.
NATURE CELL BIOLOGY (2002)
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-Kinase/Akt pathway
BD Manning et al.
MOLECULAR CELL (2002)
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1
T Radimerski et al.
NATURE CELL BIOLOGY (2002)
Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2
LY Rui et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
XS Gao et al.
GENES & DEVELOPMENT (2001)
Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size
CJ Potter et al.
CELL (2001)
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
N Tapon et al.
CELL (2001)
The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
M Hidalgo et al.
ONCOGENE (2000)
Feedback control of intercellular signalling in development
M Freeman
NATURE (2000)
Protein phosphatases and the regulation of mitogen-activated protein kinase signalling
SM Keyse
CURRENT OPINION IN CELL BIOLOGY (2000)
分享论文
