期刊
PLOS GENETICS
卷 5, 期 12, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1000791
关键词
-
资金
- NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI) [AI067854]
- National Cancer Institute, National Institutes of Health [HHSN261200800001E]
- Swiss National Science Foundation
- Infectigen Foundation
- ICREA Funding Source: Custom
- MRC [G0200585] Funding Source: UKRI
- Medical Research Council [G0200585] Funding Source: researchfish
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据