4.6 Article

Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Chemistry, Multidisciplinary

Inhibitors of Fabl, an enzyme drug target in the bacterial fatty acid biosynthesis pathway

Hao Lu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2008)

Article Biochemistry & Molecular Biology

An improved relaxed complex scheme for receptor flexibility in computer-aided drug design

Rommie E. Amaro et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2008)

Review Biochemistry & Molecular Biology

Network pharmacology: the next paradigm in drug discovery

Andrew L. Hopkins

NATURE CHEMICAL BIOLOGY (2008)

Article Multidisciplinary Sciences

Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei

Rommie E. Amaro et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Detecting evolutionary relationships across existing fold space, using sequence order-independent profile-profile alignments

Lei Xie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Environmental Sciences

Compound cytotoxicity profiling using quantitative high-throughput screening

Menghang Xia et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2008)

Article Biochemistry & Molecular Biology

Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides

Xin Hea et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Biochemical Research Methods

eHiTS: A new fast, exhaustive flexible ligand docking system

Zsolt Zsoldos et al.

JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2007)

Article Biochemistry & Molecular Biology

Surflex-Dock 2.1: Robust performance from ligand energetic modeling, ring flexibility, and knowledge-based search

Ajay N. Jain

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2007)

Article Immunology

Mechanism of thioamide drug action against tuberculosis and leprosy

Feng Wang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

Review Pharmacology & Pharmacy

Multi-target therapeutics: when the whole is greater than the sum of the parts

Grant R. Zimmermann et al.

DRUG DISCOVERY TODAY (2007)

Review Pharmacology & Pharmacy

Enoyl reductases as targets for the development of anti-tubercular and anti-malarial agents

J. S. Oliveira et al.

CURRENT DRUG TARGETS (2007)

Review Biotechnology & Applied Microbiology

Innovative lead discovery strategies for tropical diseases

Solomon Nwaka et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Article Biotechnology & Applied Microbiology

Global mapping of pharmacological space

Gaia V. Paolini et al.

NATURE BIOTECHNOLOGY (2006)

Review Pharmacology & Pharmacy

Selective optimization of side activities: the SOSA approach

CG Wermuth

DRUG DISCOVERY TODAY (2006)

Article Biochemistry & Molecular Biology

DrugBank: a comprehensive resource for in silico drug discovery and exploration

David S. Wishart et al.

NUCLEIC ACIDS RESEARCH (2006)

Article Biochemistry & Molecular Biology

High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis

Todd J. Sullivan et al.

ACS CHEMICAL BIOLOGY (2006)

Review Biotechnology & Applied Microbiology

Finding new tricks for old drugs: An efficient route for public-sector drug discovery

KA O'Connor et al.

NATURE REVIEWS DRUG DISCOVERY (2005)

Review Microbiology

Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis

K Takayama et al.

CLINICAL MICROBIOLOGY REVIEWS (2005)

Article Clinical Neurology

Tolcapone - A review of its use in the management of Parkinson's disease

GM Keating et al.

CNS DRUGS (2005)

Article Chemistry, Medicinal

ZINC - A free database of commercially available compounds for virtual screening

JJ Irwin et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2005)

Article Chemistry, Medicinal

Selective optimization of side activities: Another way for drug discovery

CG Wermuth

JOURNAL OF MEDICINAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase:: Adduct affinity and drug resistance

R Rawat et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Targeting tuberculosis and malaria through inhibition of enoyl reductase

MR Kuo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Chemistry, Medicinal

Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK

MA Seefeld et al.

JOURNAL OF MEDICINAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Association of mycothiol with protection of Mycobacterium tuberculosis from toxic oxidants and antibiotics

NA Buchmeier et al.

MOLECULAR MICROBIOLOGY (2003)

Article Biochemistry & Molecular Biology

A structure-activity relationship study of catechol-O-methyltransferase inhibitors combining molecular docking and 3D QSAR methods

AJ Tervo et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2003)

Article Public, Environmental & Occupational Health

Tolcapone-related liver dysfunction - Implications for use in Parkinson's disease therapy

N Borges

DRUG SAFETY (2003)

Article Chemistry, Medicinal

Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI)

WH Miller et al.

JOURNAL OF MEDICINAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

The Protein Data Bank

HM Berman et al.

NUCLEIC ACIDS RESEARCH (2000)