相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。The chemical versatility of natural-product assembly lines
Christopher T. Walsh
ACCOUNTS OF CHEMICAL RESEARCH (2008)
Protein-protein interactions in multienzyme megasynthetases
Kira J. Weissman et al.
CHEMBIOCHEM (2008)
Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection
Tuanh Nguyen et al.
NATURE BIOTECHNOLOGY (2008)
The crystal structure of a mammalian fatty acid synthase
Timm Maier et al.
SCIENCE (2008)
Novel intermolecular iterative mechanism for biosynthesis of mycoketide synthase by a bimodular polyketide synthase
Tarun Chopra et al.
PLOS BIOLOGY (2008)
Multienzyme docking in hybrid megasynthetases
Carsten D. Richter et al.
NATURE CHEMICAL BIOLOGY (2008)
The origins of specificity in polyketide synthase protein interactions
Mukund Thattai et al.
PLOS COMPUTATIONAL BIOLOGY (2007)
Mining and engineering natural-product biosynthetic pathways
Barrie Wilkinson et al.
NATURE CHEMICAL BIOLOGY (2007)
Identification of the missing trans-acting enoyl reductase required for phthiocerol dimycocerosate and phenolglycolipid biosynthesis in Mycobacterium tuberculosis
Roxane Simeone et al.
JOURNAL OF BACTERIOLOGY (2007)
Comprehensive analysis of distinctive polyketide and nonribosomal peptide structural motifs encoded in microbial genomes
Yohsuke Minowa et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybrids
Zhongli Xu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans
Sebastian Bergmann et al.
NATURE CHEMICAL BIOLOGY (2007)
Production of dihydroisocoumarins in Fusarium verticillioides by swapping ketosynthase domain of the fungal iterative polyketide synthase Fum1p with that of lovastatin diketide synthase
Xiangcheng Zhu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Myxobacterial natural product assembly lines: fascinating examples of curious biochemistry
Silke Christine Wenzel et al.
NATURAL PRODUCT REPORTS (2007)
The genomisotopic approach: A systematic method to isolate products of orphan biosynthetic gene clusters
Harald Gross et al.
CHEMISTRY & BIOLOGY (2007)
Single amino acid substitutions alter the efficiency of docking in modular polyketide biosynthesis
Kira J. Weissman
CHEMBIOCHEM (2006)
Structural diversity of domain superfamilies in the CATH database
Gabrielle A. Reeves et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
The structural basis for docking in modular polyketide biosynthesis
KJ Weissman
CHEMBIOCHEM (2006)
Microbial genomics for the improvement of natural product discovery
Steven G. Van Lanen et al.
CURRENT OPINION IN MICROBIOLOGY (2006)
Formation of novel secondary metabolites by bacterial multimodular assembly lines:: deviations from textbook biosynthetic logic
SC Wenzel et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2005)
Discovery of a new peptide natural product by Streptomyces coelicolor genome mining
S Lautru et al.
NATURE CHEMICAL BIOLOGY (2005)
Microbial Genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example
JB McAlpine et al.
JOURNAL OF NATURAL PRODUCTS (2005)
Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid
OA Trivedi et al.
MOLECULAR CELL (2005)
Novel polyketide synthase from Nectria haematococca
S Graziani et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2004)
Genes coding for hepatotoxic heptapeptides (microcystins) in the cyanobacterium Anabaena strain 90
L Rouhiainen et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2004)
An antibiotic factory caught in action
A Keatinge-Clay et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
The PredictProtein server
B Rost et al.
NUCLEIC ACIDS RESEARCH (2004)
NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases
MZ Ansari et al.
NUCLEIC ACIDS RESEARCH (2004)
Evidence for recombination in the microcystin synthetase (mcy) genes of toxic cyanobacteria Microcystiis spp.
Y Tanabe et al.
JOURNAL OF MOLECULAR EVOLUTION (2004)
Phylogenomic analysis of type I polyketide synthase genes in pathogenic and saprobic ascomycetes
S Kroken et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization
M Oliynyk et al.
MOLECULAR MICROBIOLOGY (2003)
The structure of docking domains in modular polyketide synthases
RW Broadhurst et al.
CHEMISTRY & BIOLOGY (2003)
SEARCHPKS: a program for detection and analysis of polyketide synthase domains
G Yadav et al.
NUCLEIC ACIDS RESEARCH (2003)
CASTp: Computed atlas of surface topography of proteins
TA Binkowski et al.
NUCLEIC ACIDS RESEARCH (2003)
The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism
S Mochizuki et al.
MOLECULAR MICROBIOLOGY (2003)
Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586
AK El-Sayed et al.
CHEMISTRY & BIOLOGY (2003)
Computational approach for prediction of domain organization and substrate specificity of modular polyketide synthases
G Yadav et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Intermodular communication in modular polyketide synthases: Structural and mutational analysis of linker mediated protein-protein recognition
P Kumar et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms
B Shen
CURRENT OPINION IN CHEMICAL BIOLOGY (2003)
Evolutionary affiliations within the superfamily of ketosynthases reflect complex pathway associations
MC Moffitt et al.
JOURNAL OF MOLECULAR EVOLUTION (2003)
Building-block selectivity of polyketide synthases
GF Liou et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2003)
A genomics-guided approach for discovering and expressing cryptic metabolic pathways
E Zazopoulos et al.
NATURE BIOTECHNOLOGY (2003)
Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602
A Rascher et al.
FEMS MICROBIOLOGY LETTERS (2003)
Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140
YQ Cheng et al.
JOURNAL OF BACTERIOLOGY (2002)
The polyketide synthase gene pks4 from Gibberella fujikuroi encodes a key enzyme in the blosynthesis of the red pigment bikaverin
P Linnemannstöns et al.
FUNGAL GENETICS AND BIOLOGY (2002)
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
J Piel
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
The calicheamicin gene cluster and its iterative type I enediyne PKS
J Ahlert et al.
SCIENCE (2002)
Biosynthesis of the enediyne antitumor antibiotic C-1027
W Liu et al.
SCIENCE (2002)
Molecular cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum
Y Abe et al.
MOLECULAR GENETICS AND GENOMICS (2002)
The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum
TW Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic
A Trefzer et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2002)
Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases
N Wu et al.
BIOCHEMISTRY (2002)
'Streptomyces nanchangensis', a producer of the insecticidal polyether antibiotic nanchangmycin and the antiparasitic macrolide meilingmycin, contains multiple polyketide gene clusters
YH Sun et al.
MICROBIOLOGY-SGM (2002)
Yersiniabactin synthetase: A four-protein assembly line producing the nonribosomal peptide/polyketide hybrid siderophore of Yersinia pestis
DA Miller et al.
CHEMISTRY & BIOLOGY (2002)
The biosynthetic gene cluster for the anticancer drug bleomycin from Streptomyces verticillus ATCC15003 as a model for hybrid peptide-polyketide natural product biosynthesis
B Shen et al.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2001)
Assessing the balance between protein-protein interactions and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules
N Wu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
Biosynthesis of the orthosomycin antibiotic avilamycin A:: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tu57 and production of new antibiotics
G Weitnauer et al.
CHEMISTRY & BIOLOGY (2001)
Multifunctional polyketide-peptide synthetase essential for albicidin biosynthesis in Xanthomonas albilineans
GZ Huang et al.
MICROBIOLOGY-UK (2001)
Molecular cloning and characterization of WdPKS1, a gene involved in dihydroxynaphthalene melanin biosynthesis and virulence in Wangiella (Exophiala) dermatitidis
B Feng et al.
INFECTION AND IMMUNITY (2001)
Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules
SY Tsuji et al.
BIOCHEMISTRY (2001)
A database and tools for 3-D protein structure comparison and alignment using the Combinatorial Extension (CE) algorithm
IN Shindyalov et al.
NUCLEIC ACIDS RESEARCH (2001)
Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806:: an integrated peptide-polyketide synthetase system
D Tillett et al.
CHEMISTRY & BIOLOGY (2000)
Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains
GL Challis et al.
CHEMISTRY & BIOLOGY (2000)
分享论文
