期刊
PLOS BIOLOGY
卷 10, 期 12, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.1001448
关键词
-
资金
- Spanish Ministry of Science and Innovation [SAF2010-21224, BES-2008-002609]
- Spanish AIDS network Red Tematica Cooperativa de Investigacion en SIDA'' [RD06/0006]
- Catalan HIV Vaccine Development Program (HIVACAT), Gala contra la sida: Barcelona
- Deutsche Forschungsgemeinschaft [TRR83, 14]
- program Jose Castillejo'' from the Spanish Ministry of Education
- Swiss National Science Foundation [31003A_132863]
- Swiss National Science Foundation (SNF) [31003A_132863] Funding Source: Swiss National Science Foundation (SNF)
- ICREA Funding Source: Custom
Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against pathogens. However, HIV-1 spread is strongly enhanced in clusters of DCs and CD4(+) T cells. Uninfected DCs capture HIV-1 and mediate viral transfer to bystander CD4(+) T cells through a process termed trans-infection. Initial studies identified the C-type lectin DC-SIGN as the HIV-1 binding factor on DCs, which interacts with the viral envelope glycoproteins. Upon DC maturation, however, DC-SIGN is down-regulated, while HIV-1 capture and trans-infection is strongly enhanced via a glycoprotein-independent capture pathway that recognizes sialyllactose-containing membrane gangliosides. Here we show that the sialic acid-binding Ig-like lectin 1 (Siglec-1, CD169), which is highly expressed on mature DCs, specifically binds HIV-1 and vesicles carrying sialyllactose. Furthermore, Siglec-1 is essential for trans-infection by mature DCs. These findings identify Siglec-1 as a key factor for HIV-1 spread via infectious DC/T-cell synapses, highlighting a novel mechanism that mediates HIV-1 dissemination in activated tissues.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据