期刊
PHYSICAL REVIEW X
卷 1, 期 1, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevX.1.011004
关键词
-
资金
- U.S. Department of Energy, Basic Energy Sciences, Office of Science [DE-AC02-06CH11357]
It is demonstrated that acoustic levitation is able to produce amorphous forms from a variety of organic molecular compounds with different glass forming abilities. This can lead to enhanced solubility for pharmaceutical applications. High-energy x-ray experiments show that several viscous gels form from saturated pharmaceutical drug solutions after 10-20 min of levitation at room temperature, most of which can be frozen in solid form. Laser heating of ultrasonically levitated drugs can also result in the vitrification of molecular liquids, which is not attainable using conventional amorphization methods.
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