期刊
PATHOGENS AND GLOBAL HEALTH
卷 107, 期 5, 页码 217-223出版社
TAYLOR & FRANCIS LTD
DOI: 10.1179/2047773213Y.0000000103
关键词
Global alert; Avian influenza; H5N1; H7N9
资金
- Higher Education Research Promotion and National Research University Project of Thailand, Office of the Higher Education Commission [HR1155A]
- Center of Excellence in Clinical Virology, Chulalongkorn University and Hospital, Centenary Academic Development Project
- RGJ PhD program of the Thailand Research Fund
- Thailand Research Fund [DPG5480002]
- Integrated Innovation Academic Center
- Chulalongkorn University Centenary Academic Development Project [CU56-HR01]
- King Chulalongkorn Memorial Hospital, National Research Council of Thailand
Outbreak of a novel influenza virus is usually triggered by mutational change due to the process known as 'antigenic shift' or re-assortment process that allows animal-to-human or avian-to-human transmission. Birds are a natural reservoir for the influenza virus, and subtypes H5, H7, and H9 have all caused outbreaks of avian influenza in human populations. An especially notorious strain is the HPAI influenza virus H5N1, which has a mortality rate of approximately 60% and which has resulted in numerous hospitalizations, deaths, and significant economic loss. In March 2013, in Eastern China, there was an outbreak of the novel H7N9 influenza virus, which although less pathogenic in avian species, resulted in 131 confirmed cases and 36 deaths in humans over a two-month span. The rapid outbreak of this virus caused global concern but resulted in international cooperation to control the outbreak. Furthermore, cooperation led to valuable research-sharing including genome sequencing of the virus, the development of rapid and specific diagnosis, specimen sharing for future studies, and vaccine development. Although a H7N9 pandemic in the human population is possible due to its rapid transmissibility and extensive surveillance, the closure of the live-bird market will help mitigate the possibility of another H7N9 outbreak. In addition, further research into the source of the outbreak, pathogenicity of the virus, and the development of specific and sensitive detection assays will be essential for controlling and preparing for future H7N9 outbreaks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据