期刊
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
卷 117, 期 1, 页码 89-95出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.oooo.2013.09.007
关键词
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资金
- Natural Science Foundation of Guangdong Province [S2012010010382]
- Fundamental Research Plan of Shenzhen City [201105140031398026, 20120601120612815]
Objective. The aim of this study was to examine the expression of several cancer-related long non-coding RNAs (lncRNAs) in patients with tongue squamous cell carcinoma (TSCC) and to explore its clinical significance. Study Design. A total of 94 TSCC tissue specimens and matched adjacent normal tissue specimens were collected from patients undergoing surgery for TSCC. Differences in the expression of cancer-related lncRNAs were examined via quantitative reverse transcriptase polymerase chain reaction. WST-1 assay and transwell migration assay were carried out to estimate the proliferation and migration abilities of TSCC cells with different expression levels of urothelial cancer-associated 1 (UCA1) lncRNA. Results. The expression levels of lncRNA UCA1 were significantly elevated in TSCC tissues (P < .0001) and were statistically correlated with lymph node metastasis (P = .0371). Over-expression of UCA1 lncRNA could promote metastatic but not proliferation ability of TSCC cells. Conclusions. Expression of UCA1 lncRNA was enhanced in TSCCs and may play a role in tumor metastasis.
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