期刊
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
卷 115, 期 2, 页码 E7-E15出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.oooo.2011.09.034
关键词
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资金
- Dental Research Center, Shahid Beheshti Medical University, Tehran, Islamic Republic of Iran
Objective. This study aimed to assess NanoBone as a carrier construct for mesenchymal stem cells (MSCs) and platelet-rich growth factor (PRGF). Study Design. In the calvarial bone of 8 mature New Zealand White male rabbits, four 8-mm defects were created. Each defect received one of the following treatments: Group 1, 0.2 mg Nano-hydroxyapatite (HA) granule + 2 mL culture medium; Group 2, 0.2 mg Nano-HA + 1 mL autologous PRGF + 2 mL acellular culture medium; Group 3, 0.2 mg Nano-HA + 2 mL culture medium containing 100,000 autogenous MSCs; Group 4, 0.2 mg Nano-HA + 2 mL culture medium containing 100,000 autogenous MSCs + 1 mL autologous PRGF. Result. Histomorphometric analysis at 6 and 12 weeks demonstrated significantly higher bone formation in group 4 (29.45% and 44.55%, respectively) (P < .05). Bone formation in groups 1, 2, and 3 were as follows: 11.35% and 32.53%, 29.10% and 39.74%, and 25.82% and 39.11%, respectively. Conclusions. NanoBone with MSCs and PRGF seems to be an effective combination for bone regeneration in a rabbit calvaria model. (Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115:e7-e15)
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