High throughput fabrication of curcumin embedded gelatin-polylactic acid forcespun fiber-aligned scaffolds for the controlled release of curcumin

The aim of current study is to fabricate implantable curcumin embedded gelatin/polylactic acid/curcumin (GL/PLA/Cur) aligned fiber scaffolds by forcespinning((R)), which might have a potential application in drug delivery and cancer therapy. Fourier Transform Infrared Spectroscopy reveals the hydrogen bonding interactions between GL, PLA, and curcumin. In vitro curcumin drug release from GL/PLA/Cur fiber scaffolds is investigated and sustained release is observed over 15 days. Further, cell viability assay reveals that GL/PLA/Cur aligned fibers show excellent growth of human fibroblast cells. These results strongly suggest that the curcumin bearing GL/PLA/Cur composite fibers may show the potential application in cancer therapy, drug delivery, and wound dressing.