期刊
JOURNAL OF SAUDI CHEMICAL SOCIETY
卷 18, 期 5, 页码 535-540出版社
ELSEVIER
DOI: 10.1016/j.jscs.2011.10.023
关键词
Multi-component; Dihydropyrano(c)chromene; Pyrano[2,3-d] pyrimidine; DABCO; Antibacterial activity
A simple and efficient one-pot synthesis of heteroaryl substititued dihydropyrano(c)chromenes and pyrano[2,3-d]pyrimidines has been developed via initial Knoevenagel, subsequent Micheal and final heterocyclization reactions of heteroaryl aldehyde, malononitrile and barbituric acid/ dimedone. 1,4-Diazabicyclo [2.2.2] octane (DABCO) has been used as a catalyst. Short reaction time, environment friendly procedure and excellent yields are the main advantages of this procedure. All synthesized compounds have shown good antimicrobial activity against different microbial stains. (C) 2011 Production and hosting by Elsevier B.V. on behalf of King Saud University.
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