DABCO promoted one-pot synthesis of dihydropyrano(c)chromene and pyrano [2,3-d]pyrimidine derivatives and their biological activities

A simple and efficient one-pot synthesis of heteroaryl substititued dihydropyrano(c)chromenes and pyrano[2,3-d]pyrimidines has been developed via initial Knoevenagel, subsequent Micheal and final heterocyclization reactions of heteroaryl aldehyde, malononitrile and barbituric acid/ dimedone. 1,4-Diazabicyclo [2.2.2] octane (DABCO) has been used as a catalyst. Short reaction time, environment friendly procedure and excellent yields are the main advantages of this procedure. All synthesized compounds have shown good antimicrobial activity against different microbial stains. (C) 2011 Production and hosting by Elsevier B.V. on behalf of King Saud University.