期刊
LANCET DIABETES & ENDOCRINOLOGY
卷 3, 期 1, 页码 75-89出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S2213-8587(14)70148-2
关键词
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资金
- ZonMw, Netherlands Organisation for Health Research and Development [91711384]
- Netherlands Heart Foundation [2010T073]
- European Regional Development Fund as part of Het Operationeel Programma Zuid-Nederland (OP-ZUID)
- province of Limburg
- Department of Economic Affairs of Netherlands [31O.041]
- Stichting de Weijerhorst
- Pearl String Initiative Diabetes
- Cardiovascular Centre Maastricht
- Cardiovascular Research Institute Maastricht (CARIM)
- School for Nutrition, Toxicology and Metabolism (NUTRIM)
- Stichting Annadal
- Health Foundation Limburg
Type 2 diabetes is associated with cognitive dysfunction and structural brain changes. Abnormalities in glucose regulation are involved in several complications related to type 2 diabetes, but their role in these cerebral complications is unclear. We systematically reviewed studies of the association between glucose regulation (glycaemia, hypoglycaemic events, insulin concentration, insulin resistance, and glucose-lowering treatment) and cognitive function and brain abnormalities on MRI in people with type 2 diabetes. The 86 papers included showed that glycaemia, particularly high HbA(1c) concentration and glucose variability, are negatively associated with cognitive function in people with type 2 diabetes without dementia. However, the strength of this association is weak, and HbA(1c) generally accounted for less than 10% of the variance in cognition. Importantly, few studies have measured long-term cerebral outcomes, such as dementia and structural brain changes on MRI, and the effect of glucose-lowering treatment on these outcomes. More randomised controlled trials are needed to establish the effect of glucose-lowering treatment on long-term cognitive function in people with type 2 diabetes.
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