期刊
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
卷 67, 期 3, 页码 169-176出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.vascn.2013.01.009
关键词
Animal models; Animal welfare; Refinement; Three Rs; Experimental autoimmune encephalomyelitis; Multiple sclerosis
资金
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) [G0700639/1] Funding Source: researchfish
This report is based on discussions and submissions from an expert working group consisting of veterinarians, animal care staff and scientists with expert knowledge relevant to the field. It aims to facilitate the implementation of the Three Rs (replacement, reduction and refinement) in the use of animal models or procedures involving experimental autoimmune encephalomyelitis (EAE), an experimental model used in multiple sclerosis research. The emphasis is on refinement since this has the greatest potential for immediate implementation. Specific welfare issues are identified and discussed, and practical measures are proposed to reduce animal use and suffering. Some general issues for refinement are summarised to help achieve this, with more detail provided on a range of specific measures to reduce suffering. (C) 2013 Elsevier Inc. All rights reserved.
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