期刊
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
卷 68, 期 2, 页码 175-183出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.vascn.2013.05.003
关键词
Anxiety; Animal model; Conditioned responses; Stress
资金
- Central Scientific Industrial Research (CSIR), New Delhi
Animal models can be used to contribute to understanding the information about molecular mechanisms involved in anxiety and for screening and developing new medications for their treatment that would be impossible in humans. The human studies have established the genetic basis of anxiety and animal studies have been used to attempt to further clarify its genetic determinants. In the field of anxiety research, animal models can be grouped into two main classes. The first involves the animal's conditioned responses to stressful and often painful events (e. g. exposure to electric foot shock) and the second includes ethologically based paradigms and involves the animal's spontaneous or natural reactions (e. g. flight, avoidance and freezing) to stress stimuli that do not explicitly involve pain or discomfort (e. g. exposure to a novel highly illuminated test chamber or to a predator). The current review enlightens the various aspects of animal model of anxiety, which may be used for research purpose. (C) 2013 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据