期刊
JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
卷 7, 期 1, 页码 -出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S179354581350051X
关键词
Glycated hemoglobin; Raman spectroscopy; PCA-LDA
资金
- National Natural Science Foundation of China [11274065, 61210016, 61308113, 61178090, 81101110]
- Science and Technology Project of Fujian Province [2012J01254, 2013J01225]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1115]
Glycated hemoglobin (HbA1c) has been increasingly accepted as the gold standard for diabetes monitoring. In this study, Raman spectroscopy was tentatively employed for human hemoglobin (Hb) biochemical analysis aimed at developing a simple blood test for diabetes monitoring. Raman spectroscopy measurements were performed on hemoglobin samples of patients (n = 39) with confirmed diabetes and healthy volunteers (n = 37). The tentative assignments of the measured Raman bands were performed to compare the difference between these two groups. Meanwhile, principal component analysis (PCA) combined with linear discriminant analysis (LDA) were employed to develop effective diagnostic algorithms for classification between normal controls and patients with diabetes. As a result, the spectral features of these two groups demonstrated two distinct clusters with a sensitivity and specificity of 92.3% and 73%, respectively. Then the effectiveness of the diagnostic algorithm based on PCA-LDA technique was confirmed by receiver operating characteristic (ROC) curve. The area under the ROC curve was 0.92, indicating a good diagnostic result. In summary, our preliminary results demonstrate that proposing Raman spectroscopy can provide a significant potential for the noninvasive detection of diabetes.
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