期刊
JOURNAL OF FLOW CHEMISTRY
卷 4, 期 4, 页码 180-184出版社
SPRINGER
DOI: 10.1556/JFC-D-14-00008
关键词
flow microreactor; lithium-halogen exchange; stop-flow method; ynolate
资金
- Program for Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries and Food Industry
- Japan Society for the Promotion of Science (JSPS) [24106731, 22390002]
- Grants-in-Aid for Scientific Research [26293004, 22390002, 26670003] Funding Source: KAKEN
We report a method for the generation and subsequent reaction of ynolates in a flow microreactor via a stop-flow process. This procedure allowed for the synthesis of ynolates at ambient temperature within 11 min via a Li-Br exchange reaction with sec-butyllithium, whereas the corresponding batch process generally requires low temperature control and extended reaction times of up to 1 h. The stop-flow method is especially useful for optimizing the reaction time without having to use various microtube lengths. The resulting ynolates were applied to the olefination of carbonyl compounds and to pyrrole synthesis. These results indicate the practical utility of the ynolate reaction and should contribute to progress in flash chemistry.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据