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ATHEROSCLEROSIS (2009)
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Sabine Ruetti et al.
ENDOCRINOLOGY (2009)
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Nabil G. Seidah
EXPERT OPINION ON THERAPEUTIC TARGETS (2009)
PCSK9 Impedes Hepatitis C Virus Infection In Vitro and Modulates Liver CD81 Expression
Patrick Labonte et al.
HEPATOLOGY (2009)
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Charles Gyamera-Acheampong et al.
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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
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Joyce C. Y. Chan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Adverse Effects of Statins - Mechanisms and Consequences
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CURRENT DRUG SAFETY (2009)
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ATHEROSCLEROSIS (2008)
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Yasuko Miyake et al.
ATHEROSCLEROSIS (2008)
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Dayami Lopez
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2008)
Genetic Loci Associated With Plasma Concentration of Low-Density Lipoprotein Cholesterol, High-Density Lipoprotein Cholesterol, Triglycerides, Apolipoprotein A1, and Apolipoprotein B Among 6382 White Women in Genome-Wide Analysis With Replication
Daniel I. Chasman et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2008)
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DRUG NEWS & PERSPECTIVES (2008)
PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1
Mary Cabell Jonas et al.
EMBO REPORTS (2008)
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Michel Chretien et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2008)
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FEBS JOURNAL (2008)
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Ahmed Zaid et al.
HEPATOLOGY (2008)
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Plasma PCSK9 levels are significantly modified by statins and fibrates in humans
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LIPIDS IN HEALTH AND DISEASE (2008)
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
Cristen J. Willer et al.
NATURE GENETICS (2008)
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Sekar Kathiresan et al.
NATURE GENETICS (2008)
Molecular population genetics of PCSK9:: a signature of recent positive selection
Keyue Ding et al.
PHARMACOGENETICS AND GENOMICS (2008)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
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TRENDS IN BIOCHEMICAL SCIENCES (2008)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
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Francine Sirois et al.
GENETIC TESTING (2008)
Evidence for Positive Selection in the C-terminal Domain of the Cholesterol Metabolism Gene PCSK9 Based on Phylogenetic Analysis in 14 Primate Species
Keyue Ding et al.
PLOS ONE (2007)
The self-inhibited structure of full-length PCSK9 at 1.9 Å reveals structural homology with resistin within the C-terminal domain
Eric N. Hampton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
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ATHEROSCLEROSIS (2007)
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The proprotein convertases are potential targets in the treatment of dyslipidemia
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JOURNAL OF MOLECULAR MEDICINE-JMM (2007)
Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat a of low density lipoprotein receptor decreases receptor recycling and increases degradation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat
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DEVELOPMENTAL BIOLOGY (2007)
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TRAFFIC (2007)
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STRUCTURE (2007)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
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NEUROSCIENCE LETTERS (2006)
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ENDOCRINOLOGY (2006)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
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HUMAN MUTATION (2006)
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NEW ENGLAND JOURNAL OF MEDICINE (2006)
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AMERICAN JOURNAL OF HUMAN GENETICS (2006)
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JOURNAL OF MOLECULAR MEDICINE-JMM (2005)
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JOURNAL OF LIPID RESEARCH (2005)
A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis
SN Chen et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2005)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Inhibiting uterine PC6 blocks embryo implantation: An obligatory role for a proprotein convertase in fertility
GY Nie et al.
BIOLOGY OF REPRODUCTION (2005)
Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
C Jonathan et al.
NATURE GENETICS (2005)
Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia
TP Leren
CLINICAL GENETICS (2004)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2004)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
M Abifadel et al.
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