期刊
JOURNAL OF DIABETES
卷 3, 期 3, 页码 225-231出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1753-0407.2011.00132.x
关键词
apelin; diabetes; glucose; insulin resistance; lipolysis
资金
- National Institutes of Health Mentored Clinical Scientist Research Career Development Award [1K08 DK080463]
- American Diabetes Association Basic Science Award [1-10-BS-204]
- American Heart Association [0840172N]
Apelin is a newly discovered peptide hormone that has recently been linked to insulin resistance and obesity. Data collected from both the clinical and basic research settings show that apelin: (i) is correlated with the states of insulin resistance and obesity; (ii) stimulates glucose utilization; (iii) decreases insulin secretion; and (iv) negatively regulates catecholamine-mediated lipolysis. These and other lines of evidence demonstrate that apelin may be a potentially viable candidate in the search for treatments for Type 2 diabetes and the insulin resistance (metabolic syndrome). The present review summarizes the literature on the regulation by apelin of glucose and lipid metabolism and the signaling pathways involved.
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