期刊
BEHAVIOURAL BRAIN RESEARCH
卷 278, 期 -, 页码 375-384出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2014.10.011
关键词
Reconsolidation; Memory; Prediction error; NMDAR; Dopamine
资金
- Australian Research Council Discovery Early Career Research Award [DE140101071]
- Leverhulme Trust Grant [F/00 094/BK]
- BBSRC grant [BB/J014982/1]
- Biotechnology and Biological Sciences Research Council [BB/J014982/1] Funding Source: researchfish
- Medical Research Council [MR/M017753/1] Funding Source: researchfish
- BBSRC [BB/J014982/1] Funding Source: UKRI
- MRC [MR/M017753/1] Funding Source: UKRI
Memories are not static imprints of past experience, but rather are dynamic entities which enable us to predict outcomes of future situations and inform appropriate behaviours. In order to maintain the relevance of existing memories to our daily lives, memories can be updated with new information via a process of reconsolidation. In this review we describe recent experimental advances in the reconsolidation of both appetitive and aversive memory, and explore the neuronal mechanisms that underpin the conditions under which reconsolidation will occur. We propose that a prediction error signal, originating from dopaminergic midbrain neurons, is necessary for destabilisation and subsequent reconsolidation of a memory. (C) 2014 Elsevier B.V. All rights reserved.
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