期刊
JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS
卷 10, 期 2, 页码 67-81出版社
SAGE PUBLICATIONS LTD
DOI: 10.5301/JABFM.2012.9418
关键词
Biomaterials; Cell delivery; Injectable hydrogels; Microspheres; Natural polymers; Tissue regeneration
资金
- Fondazione Cassa di Risparmio di Trento e Rovereto
Natural polymers, because of their biocompatibility, availability, and physico-chemical properties have been the materials of choice for the fabrication of injectable hydrogels for regenerative medicine. In particular, they are appealing materials for delivery systems and provide sustained and controlled release of drugs, proteins, gene, cells, and other active biomolecules immobilized. In this work, the use of hydrogels obtained from natural source polymers as cell delivery systems is discussed. These materials were investigated for the repair of cartilage, bone, adipose tissue, intervertebral disc, neural, and cardiac tissue. Papers from the last ten years were considered, with a particular focus on the advances of the last five years. A critical discussion is centered on new perspectives and challenges in the regeneration of specific tissues, with the aim of highlighting the limits of current systems and possible future advancements.
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