期刊
JOURNAL OF VETERINARY CARDIOLOGY
卷 17, 期 -, 页码 S244-S257出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jvc.2015.03.008
关键词
HCM; Feline; Screening; Echocardiography; Shelter
资金
- Everts Luff feline endowment
- IDEXX Laboratories
Objectives: Hypertrophic cardiomyopathy (HCM) appears to be common in cats and, based on pilot data, a prevalence of 15% has been hypothesized. The objectives were to screen a large population of apparently healthy adult cats for cardiac disease, and identify factors associated with a diagnosis of HCM. Animals: A total of 1007 apparently healthy cats >= 6 months of age. Methods: In this prospective, cross-sectional study, the inclusion criteria were: apparently healthy cats, aged >= 6 months, available for rehoming over a 17-month period from two rehoming centres. Hypertensive or hyperthyroid cats were excluded. Body weight, body condition score, auscultation, systolic blood pressure and two-dimensional (2-D) echocardiography were evaluated. Cats with left ventricular end diastolic wall thickness >= 6 mm on 2-D echocardiography were considered to have HCM. Results: Complete data were obtained in 780 cats. Heart murmur prevalence was 40.8% (95% confidence interval (CI) 37.3-44.3%), 70.4% of which were considered functional. The prevalence of HCM was 14.7% (95% CI 12.3-17.4%), congenital disease 0.5% (95% CI 0.1-1.3%), and other cardiomyopathies 0.1% (95% CI 0.0-0.7%). The HCM prevalence increased with age. The positive predictive value of a heart murmur for indicating HCM was 17.9-42.6% (higher in old cats), and the negative predictive value was 90.2-100% (higher in young cats). The factors associated with a diagnosis of HCM in binary logistic regression models were male sex, increased age, increased body condition score and a heart murmur (particularly grade III/VI or louder). Conclusions: Hypertrophic cardiomyopathy is common in apparently healthy cats, in contrast with other cardiomyopathies. Heart murmurs are also common, and are often functional. (C) 2015 Elsevier B.V. All rights reserved.
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