期刊
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
卷 113, 期 6, 页码 776-785出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jand.2013.01.019
关键词
Fruit and vegetable intake; Oxidative stress; Premenopausal women; Antioxidant
资金
- National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development
Background Oxidative stress has been associated with a variety of chronic diseases and reproductive disorders. Fruits and vegetables (F/V) may contribute to antioxidant vitamin and micronutrient levels and reduce oxidative stress. Objective To investigate the effect of meeting the 5 A Day For Better Health Program recommendation for F/V consumption on biomarkers of oxidative damage and antioxidant defense. Design In this longitudinal study, healthy premenopausal women (n=258) were followed for <= 2 menstrual cycles with <= 16 oxidative stress measures timed to cycle phase. Main outcome measures Plasma concentrations of F-2-isoprostane, 9-hydroxyoctadecadieneoic acid, 13-hydroxyoctadecadieneoic acid, erythrocyte activity of superoxide dismutase, glutathione reductase, and glutathione peroxidase, as well as blood micronutrient concentrations were measured. Dietary intake was assessed by food frequency questionnaires (FFQs) (1 per cycle), and 24-hour recalls (<= 4 per cycle). Statistical analyses performed Fruit and vegetable servings were dichotomized based on the recommendation to consume five servings of F/V each day. Linear mixed models with repeated measures were used to analyze lipid peroxidation markers, antioxidant vitamins, and antioxidant enzymes by cycle phase and in association with usual F/V intake. Results For both 24-hour recall (timed to cycle phase) and cycle-specific FFQ meeting the recommendation to consume five servings of F/V each day was associated with decreased F-2-isoprostanes (24-hour recall beta=-.10 [95% CI, -0.12 to -0.07]; FFQ beta=-.14 [95% CI, -0.18 to -0.11]). Glutathione reductase was lower in association with typical consumption of five or more servings of F/V by FFQ but not in the phase-specific analysis. Higher levels of ascorbic acid, lutein, beta carotene, and beta cryptoxanthin were observed with both intake measures. Conclusions Meeting the 5 A Day For Better Health Program recommendation was associated with lower oxidative stress and improved antioxidant status in analyses of typical diet (via FFQ) and in menstrual cycle phase-specific analyses using 24-hour recalls. Green salads were commonly eaten and increasing intake of salads may be a useful strategy to influence oxidation in reproductive aged women.
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