期刊
JOURNAL OF IMMUNOLOGY RESEARCH
卷 2015, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2015/145859
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资金
- National Natural Science Foundation of China [81273268, 81102271]
- Suzhou city [SWG0904, SZS201109]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Qing Lan Project of Jiangsu Province
- Jiangsu Provincial Innovative Research Team
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1075]
The mammalian intestinal microbiota is a complex ecosystem that plays an important role in host immune responses. Recent studies have demonstrated that alterations in intestinal microbiota composition are linked to multiple inflammatory diseases in humans, including acute graft-versus-host disease (aGVHD). aGVHD is one of the major obstacles in allogeneic hematopoietic stem cell transplantation (allo-HSCT), characterized by tissue damage in the gastrointestinal (GI) tract, liver, lung, and skin. Here, we review the current understanding of the role of intestinal microbiota in the control of immune responses during aGVHD. Additionally, the possibility of using probiotic strains for potential treatment or prevention of aGVHD will be discussed.
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