期刊
BEHAVIOURAL BRAIN RESEARCH
卷 284, 期 -, 页码 103-111出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2015.02.010
关键词
Restraint; Anxiety behavior; Dark cycle; Light cycle
资金
- KAKENHI [25460099, 26293020, 26670122]
- Neuropsychiatry Drug Discovery Consortium
- Osaka University
- Takeda Science Foundation (Japan)
- Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers
- Grants-in-Aid for Scientific Research [25460099, 14J06155, 15H01288, 26293020, 26670122] Funding Source: KAKEN
Stress during developmental stage may cause psychological morbidities, and then the studies on stress are important in adolescent rodents. Restraint is used as a common stressor in rodents and the effects of restraint during the light cycle have been studied, but those of restraint during the dark cycle have not. The present study examined the effects of restraint during the light and dark cycles on anxiety behaviors in adolescent mice. Restraint for 3 h during either the light or dark cycle impaired memory function in the fear conditioning test, but did not affect locomotor activity. In the elevated plus-maze test, restraint during the dark cycle reduced anxiety-like behaviors in mice. Repeated exposure to a 3-h period dark cycle restraint for 2 weeks had a similar anxiolytic-like effect. In contrast, restraint for 3 h during the light cycle produced anxiety behavior in adolescent, but not adult, mice. The light cycle stress increased plasma corticosterone levels, and elevated c-Fos expression in the prefrontal cortex, paraventricular hypothalamic nucleus, basolateral amygdala and dentate gyrus, and enhanced serotonin turnover in the hippocampus and striatum, while the dark cycle stress did not. There was no difference in the stress-mediated reduction in pentobarbital-induced sleeping time between dark and light cycle restraint. These findings suggest that the anxiolytic effect of dark cycle restraint is mediated by corticosterone, serotonin or y-aminobutyric acid-independent mechanisms, although the anxiogenic effect of light cycle restraint is associated with changes in plasma corticosterone levels and serotonin turnover in specific brain regions. (C) 2015 Elsevier B.V. All rights reserved.
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