期刊
HUMAN VACCINES & IMMUNOTHERAPEUTICS
卷 10, 期 11, 页码 3270-3285出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/21645515.2014.979640
关键词
cancer; inflammation; innate immunity; PRRs; type I interferon; PRRs; pathogen recognition receptors; PAMPs; pathogen-associated molecular patterns; DAMPs; danger-associated molecular patterns; TLRs; Toll-like receptors; RLRs; RIG-I-like receptors; NLRs; Nod- like receptors; ALRs; AIM2-like receptors; CLRs; C-type lectin receptors; IFN; interferon; DCs; dendritic cells; NOD; nucleotide-binding oligomerization domain; LRR; leucine-rich repeat; RIG-I; retinoic acid-inducible gene 1; LGP 2; laboratory of genetics and physiology 2; MDA5; melanoma differentiation-associated protein 5; AIM2; absent in melanoma 2; IFI16; interferon; gamma-inducible protein 16; DDX41; DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; cGAS; cyclic GMP-AMP synthase; TIR; Toll IL-1 receptor; LPS; lipopolysaccharide; MyD88; myeloid differentiation factor 88; TIRAP; TIR domain-containing adapter protein; TRIF; TIR domain-containing adaptor inducing IFN-b; TRAM; TRIF-related adaptor molecule; SARM; sterile a- and armadillo motif-containing protein; IRAK; interleukin-1 receptor-associated kinase; TRAF; TNFR-associated factor; NEMO; NF-kB essential modulator; IKK; IkB kinase; TAK1; TGF-b-activating kinase 1; IRF; interferon regulatory factor; RIP; receptor-interacting protein; TANK; TRAF family-member-associated NF-kB activator; TBK1; TANK binding kinase 1; IKKi; inducible IkB kinase; iE-DAP; g-D-glutamyl-meso-diaminopimelic acid; MDP; muramyl dipeptide; Atg16L; autophagy related 16-like; MAVS; mitochondrial antiviral signaling protein; ASC; apoptosis-associated speck-like protein containing a CARD; CARD; caspase recruitment domain; LT; lethal toxin; NAIPs; neuronal apoptosis inhibitory proteins; STING; stimulator of interferon gene; CMV; cytomegalovirus; ER; endoplasmic reticulum; CDNs; cyclic dinucleotides; CYLD; the familial cylindromatosis tumor suppressor gene; Nrdp1; neuregulin receptor degradation protein 1; TRIMs; tripartite motif containing proteins; LBP; LPS-binding protein; SIGIRR; single Ig IL-1-related receptor; TRAILR; tumor-necrosis factor-related apoptosis-inducing ligand receptor; cIAP; cellular inhibitor of apoptosis protein; ROS; reactive oxygen species; BMM; bone marrow-derived macrophage; SOCS; suppressor of cytokine signaling; GBP5; guanylate-binding protein 5; PKC-d; protein kinase C delta; PKR; dsRNA-dependent protein kinase; ULK1; autophagy related serine threonine UNC-51-like kinase; AMPK; AMP activated protein kinase; LUBAC; linear ubiquitin assembly complex; GSK3; Glycogen synthase kinase 3; MIB; mind bomb; TRIP; TRAF-interacting protein; cDC; conventional dendritic cell; pDC; plasmacytoid dendritic cell; KSHV; Kaposi's sarcoma-associated herpesvirus; RAUL; RTA-associated E3 ligase; RACK1; receptor for activated C kinase 1; HCC; hepatocellular carcinoma
资金
- Key Basic Research Program of China [2014CB910800]
- National Natural Science Foundation of China [31370869]
- Guangdong Natural Science Funds for Distinguished Young Scholar [S2013050014772]
- National Guangdong Innovative Research Team Program [2011Y035, 201001Y0104687244]
- National Cancer Institute, NIH [R01CA101795, R01CA09327, DA030338]
- National Institute on Drug Abuse, NIH [R01CA101795, R01CA09327, DA030338]
- Cancer Prevention and Research Institute of Texas [CPRIT RP121048]
Research on innate immune signaling and regulation has recently focused on pathogen recognition receptors (PRRs) and their signaling pathways. Members of PRRs sense diverse microbial invasions or danger signals, and initiate innate immune signaling pathways, leading to proinflammatory cytokines production, which, in turn, instructs adaptive immune response development. Despite the diverse functions employed by innate immune signaling to respond to a variety of different pathogens, the innate immune response must be tightly regulated. Otherwise, aberrant, uncontrolled immune responses will lead to harmful, or even fatal, consequences. Therefore, it is essential to better discern innate immune signaling and many regulators, controlling various signaling pathways, have been identified. In this review, we focus on the recent advances in our understanding of the activation and regulation of innate immune signaling in the host response to pathogens and cancer.
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