期刊
HUMAN VACCINES & IMMUNOTHERAPEUTICS
卷 10, 期 11, 页码 3261-3269出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/21645515.2014.982996
关键词
dendritic cells; cancer immunotherapy; DAMPs; Toll-like receptors; immunogenic cell death; TRIMEL; Allogeneic melanoma cell lysate; TRIPRO; Allogeneic prostate cell lysate; Ags; Antigens; CRT; Calreticulin; CDAMs; Cell death-associated molecules; AM; Cytokine-activated monocytes; CTLs; Cytotoxic T lymphocytes; DAMPs; Damage-associated molecular patterns; DTH; Delayed-type IV hypersensitivity; DCs; Dendritic cells; GM-CSF; Granulocyte and macrophage colony stimulating factor; HSPs; Heat shock proteins; HMGB1; High-mobility group box 1 protein; ICD; Immunogenic cell death; MHC; Major histocompatibility complex; MM; Malignant melanoma; MAAs; Melanoma-associated antigens; NKT; Natural killer T cell; PAMPs; Pathogen-associated molecular patterns; PRRs; Pattern recognition receptors; PBMCs; Peripheral blood mononuclear cells; PD1; Programmed cell death protein 1; PCCL; Prostate cancer cell lysate; PSA; Prostate specific antigen; RAGE; Receptor for advanced glycation endproducts; Tregs; Regulatory T lymphocytes; SNPs; Single nucleotide polymorphisms; TCRs; T cell receptors; TLRs; Toll-like receptors; TAPCells; Tumor antigen presenting cells; TNF; Tumor necrosis factor; TAAs; Tumor-associated antigens
资金
- Millennium Science Initiative of the Ministry of Economy, Development and Tourism [P09/016-F]
- Chilean National Fund for Scientific and Technological Development [FONDECYT 1130320, 11130607, 1130324]
- [FON-DEF D11I1036]
- [PAI 82130031]
Autologous dendritic cells (DCs) loaded with tumor-associated antigens (TAAs) are a promising immunological tool for cancer therapy. These stimulate the antitumor response and immunological memory generation. Nevertheless, many patients remain refractory to DC approaches. Antigen (Ag) delivery to DCs is relevant to vaccine success, and antigen peptides, tumor-associated proteins, tumor cells, autologous tumor lysates, and tumor-derived mRNA have been tested as Ag sources. Recently, DCs loaded with allogeneic tumor cell lysates were used to induce a potent immunological response. This strategy provides a reproducible pool of almost all potential Ags suitable for patient use, independent of MHC haplotypes or autologous tumor tissue availability. However, optimizing autologous tumor cell lysate preparation is crucial to enhancing efficacy. This review considers the role of cancer cell-derived lysates as a relevant source of antigens and as an activating factor for ex vivo therapeutic DCs capable of responding to neoplastic cells. These promising therapies are associated with the prolonged survival of advanced cancer patients.
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