期刊
HUMAN VACCINES & IMMUNOTHERAPEUTICS
卷 10, 期 10, 页码 2896-2902出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/hv.29784
关键词
respiratory; virus; RSV; influenza; bacterial; lysates; extracts; adjuvants; immunomodulators
资金
- Casasco, Argentina
Respiratory viruses cause significant morbidity and mortality in infants and young children worldwide. Current strategies to modulate the immune system and prevent or treat respiratory viral infections in this age group have shown limited success. Here, we demonstrate that a lysate derived from Gram-positive and Gram-negative organisms positively modulates protective antibody responses against both respiratory syncytial virus (RSV) and influenza virus in murine models of infection. Interestingly, despite the complex mixture of Toll-like receptor (TLR) agonists present in the bacterial lysate, the modulatory effects were mostly dependent on TLR4 signaling. Our results indicate that the use of simple formulations of TLR-agonists can significantly improve the immune response against critical pediatric respiratory pathogens.
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