期刊
HUMAN VACCINES & IMMUNOTHERAPEUTICS
卷 9, 期 11, 页码 2393-2397出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/hv.25506
关键词
group A streptococcus; J8-DT; vaccination; rheumatic fever; rheumatic heart disease
资金
- National Heart Foundation of Australia
- National Health and Medical Research Council (Australia)
- Prince Charles Hospital foundation
- Cooperative Research Centre for vaccine Technology
- National Institute of Health (USA)
- Cooperative Research Centre for Aboriginal Health
There has long been interest and demand for the development of a vaccine to prevent infections caused by the Gram-positive organism group A streptococcus. Despite numerous efforts utilizing advanced approaches such as genomics, proteomics and bio-informatics, there is currently no vaccine. Here we review various strategies employed to achieve this goal. We also discuss the approach that we have pursued, a non-host reactive, conformationally constrained minimal B cell epitope from within the C-repeat region of M-protein, and the potential limitations in moving forward.
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